Scatter and Shatter: Centrosome Declustering is an Attractive Chemotherapeutic Strategy

The centrosome is a non-membranous organelle often found near the cell center, as per its namesake. It consists of two orthogonallyoriented centrioles enmeshed within a conglomeration of proteins called the pericentriolar material (PCM). Despite its diminutive size, the centrosome assumes a highly influential position in metazoan cells, serving as the major microtubule organizing center (MTOC). As such, the centrosome impacts a vast array of cellular processes, such as mitotic spindle formation and orientation, cell polarization, directional migration, cell signaling through the primary cilium, and locomotion via flagella [1]. Furthermore, the centrosome serves various MTOC-independent functions in cell cycle progression, such as G1/S transition, mitotic entry, anaphase onset, and cytokinesis. Consequently, disturbances in centrosome function typically engender far-reaching consequences.